Ritalin Essay

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Ritalin

The Babysitter of the 90's

07/03/2000

Prepared for Nursing 2116

by Tracey Hardin

Ritalin (Methylphenidate) is a mild CNS stimulant. In medicine, Ritalin's primary use is

treatment of Attention Deficit /Hyperactive Disorder (ADHD). The mode of action in humans is

not completely understood, but Ritalin presumably activates the arousal system of the brain

stem and the cortex to produce its stimulant effect. Recently, the frequency of diagnosis for

ADHD has increased dramatically. More children and an increasing number of adults are being

diagnosed with ADHD. According to the Drug Enforcement Agency (DEA) (Bailey 1995),

prescriptions for Ritalin have increased more than 600% in the past five years. Ritalin has a

long history of controversy regarding side effects and potential for abuse, however it greatly

benefits those with ADHD.

Ritalin (Methylphenidate) is manufactured by CIBA-Geigy Corporation. It is supplied in 5

mg., 10 mg., and 20 mg. tablets, and in a sustained release form, Ritalin SR, in 20 mg. tablets.

It is readily water soluble and is intended for oral use. It is a Schedule II Controlled Substance

under both the Federal and Vermont Controlled Substance Acts. Ritalin is primarily used in the

treatment of Attention Deficit/Hyperactive Disorder (ADHD) (Bailey 1995).

ADHD is a condition most likely based in an inefficiency and inadequacy of Dopamine

and Norepinephrine hormone availability, typically occurring when a person with ADHD tries to

concentrate. Ritalin improves the efficiency of the hormones Dopamine and Norepinephrine,

increasing the resources for memory, focus, concentration and attention (Clark 1996). Ritalin

has been used for more than 30 years to treat ADHD. Nervousness and insomnia are the most

common adverse reactions reported, but are usually controlled by reducing dosage or omitting

the afternoon or evening dose. Decreased appetite is also common but usually transient (Long

1996). According to Clark (1996), children, adolescents and adults diagnosed with ADHD

usually report the following effects when successfully treated with Ritalin:

•Improved concentration

•Better "focus"

•Improved ability to complete their work

•Improved intensity of attention and longer attention span

•Reduced distractibility

•Reduced impulsivity

•Reduced restlessness and overactivity

•Improved patience

•More elaborate expressive vocabulary

•Better written expression and handwriting (especially in children)

•An improved sense of "alertness"

•Improved memory for visual as well as auditory stimuli

Ritalin exhibits pharmacological activity similar to that of amphetamines. Ritalin's exact

mechanism of action in the CNS is not fully understood, but the primary sites of activity appear

to be in the cerebral cortex and the subcortical structures including the thalamus. Ritalin blocks

the reuptake mechanism present in dopaminergic neurons. As a result, sympathomimetic

activity in the central nervous system and in the peripheral nervous system increases.

Ritalin-induced CNS stimulation produces a decreased sense of fatigue, an increase in motor

activity and mental alertness, mild euphoria, and brighter spirits. In the PNS, the actions of

Ritalin are minimal at therapeutic doses (Clinical Pharmacology Online 1997).

Ritalin is the quickest of all oral ADHD stimulant medications in onset of action: it starts

to achieve benefit in 20 - 30 minutes after administration, and is most effective during the

upward ‘slope' and peak serum levels. Ritalin's effect is brief: Most people experience 2-3

hours of benefit, but after 3 hours, benefits drop off rapidly. Some individuals, especially

children, may obtain 4 or even 5 hours of positive effect (Clark 1996).

Recently, there has been a dramatic upsurge of interest in using stimulants (mainly

Ritalin) for children and adults for the increasingly popular diagnosis of ADHD. According to

Persky (1996), the high frequency of the diagnosis of ADHD is a uniquely American

phenomenon. Children and adults are now under greater pressure to perform and to do well

academically or in the workplace. The chilling message in school and at work is "Perform or

Else." Because of this high intensity atmosphere, the use of Ritalin has become attractive. This

has resulted in an acute "epidemic" of ADHD and the treatment of choice is Ritalin (Persky

1996). For example, after education reforms spearheaded by Ross Perot in Texas in 1984,

Ritalin use in the state doubled. One Texas mother says she is being hounded by teachers to

put her two boys on Ritalin against their psychologist's advice. Another mother says she had to

ask a school board member to intervene when teachers at her child's school also pressed for

Ritalin use("Critics say Ritalin," Houston Chronicle, May 1996). Ritalin is an effective treatment

for people with ADHD. Because it allows them to filter out distractions...

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