Anabolic Steroids Term paper

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Anabolic Steroids

Description:

Anabolic steroids are performance enhancing drugs. They are a

synthetic form of the chemical testosterone that is normally found in the body.

By taking anabolic steroids, a person's testosterone level can be raised up to a

hundred times more than the usual amount of 2.5 to 10 mg. Per day. The increase

in testosterone increases anabolic activity, which results in greater muscle

bulk. It also increases protein synthesis and androgenic activity (enhanced

secondary sexual characteristics) in males. The users of steroids want to

increase the anabolic effects and reduce the androgenic effects, but no steroid

is known to have just anabolic effects.

Use:

Anabolic steroids can be taken in two ways, by injection or they can be

taken orally. Both oral and injected steroids carry benefits and adverse

effects. Orally taken steroids are well absorbed into the stomach and they are

excreted fairly rapidly. The bad side of taking oral steroids is that they are

more toxic than injected steroids. They are highly potent, which makes the risk

of overdosing very high. Steroids that are injected are less toxic to the liver

and are less potent than oral steroids on an equal dosage basis. Injected

steroids have a delayed take up, which makes them last longer. It also allows

them to be detected in drug tests for a longer period of time.

How they work in the body:

When anabolic steroids are introduced into the body, under certain

conditions they increase: protein synthesis, lean body mass, and the nitrogen

balance in the body. A steroid receptor is formed which stimulates the

synthesis of enzymes. With the stimulus of enzymes in the body, protein

synthesis is also increased. One enzyme system that is placed into the body by

the receptor is the ribonucleic acid (RNA)-polymerose system. This system

promotes cellular protein metabolism and synthesis which utilizes nitrogen. By

utilizing the nitrogen, the anabolic action is increased, which leads to larger

muscle size and strength. Anabolic steroids also increase nitrogen retention in

the body. They move the nitrogen equilibrium to the positive side. This allows

the body to utilize ingested protein better, but the balance does not last

forever. The body's homeostatic mechanisms regulate the balance and change it

back to normal. This is one set back to anabolic steroid use. In order to gain

lean body mass a person may have to eat up to 10,000 calories / day and must

continue a rigorous weight training program. If this is not followed, taking

the steroids would be worthless.

Adverse Effects:

Despite the increase in muscle size and strength, anabolic steroids

carry an even greater risk, the side effects. The side effects can be permanent

or even deadly. Serious side effects are seen in the liver, the cardiovascular,

central nervous and reproductive/endocrine systems.

One major side effect that can be found in the liver is hepatotoxicity.

This is the poisoning of the liver. It shuts down the liver's ability to

process blood, which in turn shuts down the whole body. Prolonged use of

anabolic steroids can cause cholestosis and jaundice (yellowish coloring of the

eyes, skin and body fluids). Even though most adverse side effects in the liver

are reversible upon discontinuation of steroids, fatalities can occur. The

fatalities occur from hepatic cholestosis, liver tumors or peliosis hepatitis

(blood filled cysts that can rupture and cause bleeding and liver failure).

Very noticeable effects occur in the reproductive system. In males the

testicles shrink by about 20%. They become impotent. Their sperm count can

decrease by 90%. Also gynecomastia can be seen in males. Gynecomastia is the

enlargement of the breasts. One adverse effect that can be seen in both males

and females using steroids is inappropriate hair growth. In females, anabolic

steroids can cause irregularities in their menstrual cycles. It causes the

female voice to deepen and clitoral hypertrophy. Clitoral hypertrophy is the

enlargement of the clitoris. Many of these things are irreversible, but...

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