Term paper on Alzheimer S Disease

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ALZHEIMER'S DISEASE



We are currently living in the age of technology. Our advancements in the

past few decades overshadow everything learned in the last 2000 years. With the

elimination of many diseases through effective cures and treatments, Canadians

can expect to live a much longer life then that of their grandparents. In 1900

about 4% of the Canadian population was over the age of 65. In 1989 that figure

tripled to 12% and the government expects that figure to rise to 23% by the year

2030 (Medical,1991,p.13). This increase has brought with it a large increase in

diseases associated with old age. Alzheimer's dementia (AD) is one of the most

common and feared diseases afflicting the elderly community. AD, once thought to

be a natural part of aging, is a severely debilitating form of mental dementia.

Although some other types of dementia are curable or effectively treatable,

there is currently no cure for the Alzheimer variety.

A general overview of Alzheimer's disease including the clinical

description, diagnosis, and progression of symptoms, helps one to further

understand the treatment and care of patients, the scope of the problem, and

current research.

The clinical definition of dementia is "a deterioration in intellectual

performance that involves, but is not limited to, a loss in at least 2 of the

following areas: language, judgement, memory, visual or depth perception, or

judgement interfering with daily activities" (Institute,1996, p.4).

The initial cause of AD symptoms is a result of the progressive

deterioration of brain cells (neurons) in the cerebral cortex of the brain. This

area of the brain, which is the largest and uppermost portion, controls all our

thought processes, movement, speech, and senses. This deterioration initially

starts in the area of the cortex that is associated with memory and then

progresses into other areas of the cortex, then into other areas of the brain

that control bodily function. The death of these cells causes an interruption of

the electrochemical signals between neurons that are a key to cognitive as well

as bodily functioning.

Currently AD can only be confirmed at autopsy. After death the examined

brain of an Alzheimer victim shows two distinct characteristics. The first is

the presence of neuritic plaques in the cerebral cortex and other areas of the

brain including cerebral blood vessels. These plaques consist of groups of

neurons surrounded by deposits of beta-amyloid protein. The presence of these

plaques is also common to other types of dementia.

The second characteristic, neurofibliary tangles, is what separates AD from

all other forms of dementia. Neurofibliary tangles take place within the

disconnected brain cells themselves. When examined under a microscope diseased

cells appear to contain spaghetti-like tangles of normally straight nerve fibers.

The presence of these tangles was first discovered in 1906 by the German

neurologist Alois Alzheimer, hence the name Alzheimer's disease.

Although the characteristics listed above are crucial to the diagnosis of

AD upon death, the clinical diagnosis involves a different process. The

diagnosis of AD is only made after all other illnesses, which may have the same

symptoms, are ruled out. The initial symptoms of AD are typical of other

treatable diseases therefore doctors are hesitant to give the diagnosis of

Alzheimer's in order to save the patient from the worsening of a treatable

disease through a misdiagnosis. Some of the initial symptoms include an

increased memory loss, changes in mood, personality, and behavior, symptoms that

are common of depression, prescription drug conflict, brain tumors, syphilis,

alcoholism, other types of dementia, and many other conditions.

The onset of these symptoms usually brings the patient to his family doctor.

The general practitioner runs a typical battery of urinalysis and blood tests

that he sends off to the lab. If the tests come back negative, and no other

cause of the symptoms is established, the patient is then refereed to a

specialist. The specialist, usually a psychiatrist, will then continue to rule

out other possible illnesses through testing. If the next battery of tests also

comes back negative then the specialist will call on a neurologist to run a

series of neurological examinations including a PET and CAT scan to rule out the

possibility of brain tumors. A spinal tap is also performed to determine the

possibility of other types of dementias. The patient will also undergo a

complete psychiatric evaluation. If the patient meets the preliminary criteria

for AD an examination of the patients medical history is also necessary to check

for possible genetic predispositions to the disease.

The psychiatric team finally meets with the neurological team to discuss

their findings. If every other possible disease is ruled out, and the results of

the psychiatric evaluation are typical to that of a person with AD, the

diagnosis of Alzheimer's disease is given.

The initial symptoms of AD are usually brushed off as a natural part of

aging. The myth that a person's memory worsens over time is just that - a myth

(Myers,1996, p.100-101). AD's victims are mostly over the age of 65 and many

delay treatment by attributing their problems to age. A victim might forget a

well known phone number or miss an important appointment. These symptoms

eventually escalate to the total disintegration of personality and all patients

end up in total nursing care.


In descending order, the patient goes from (1) decreased ability to

handle a

complex job to (2) decreased ability to handle such complex activities

of daily

life as (3) managing finances, (4) complex meal preparation and (5)

complex

marketing skills.Next comes (6) loss of ability to pick out clothing

properly, (7)

or to put on clothing properly, followed by (8) loss of ability

to handle

the mechanics of bathing properly. Then (9) progressive

difficulties with

continence and (10) toileting occur, followed by (11) very limited speech

ability

and (12) inability to speak more than a single word. Next comes (13)

loss of

ambulatory capability. Last to go are such basic functions as (14) sit

up, (15)

smile and (16) hold up one's head (Brassard,1993,p.10).


The average time from diagnosis to inevitable death is 8 years. The family

of the victim is usually able to care for the victim for an average period of

about 4 years (Alzheimer's, 1996,p.44).During the progression of the disease

between 10% and 15% of patients hallucinate and suffer delusions, 10% will

become violent and 10% suffer from seizures (Alzheimer's,1996,p.46).

Once a person is diagnosed as having AD, an assessment is made of the

disease's stage of progression and of the strengths and weaknesses of the victim

and the victim's family. There are different types of assessments available to

evaluate the level of dysfunction of the patient. Based on one of these

assessments a care plan is put together by a team consisting of a family member,

a paid or unpaid care provider, and the victim's physician. Throughout the

progression of the disease, and depending on the needs of the patient, a wide

range of expensive medication, such as psychoactive drugs to lift depression and

sedatives to control violence, may be required.

Unfortunately, although a wide range of treatments have been tested, most

prove to be ineffective. At the beginning of the disease the family is able to

look after the patient without much effort. Frequently families will hire a care

giver in order to alleviate some of the work.

Simple changes in the home can make life much easier for the sufferer, help

them keep their self esteem, and prolong their stay at home. Examples of low-

cost modifications to the environment include reducing the noise levels in the

home (telephones, radios, voices, etc.); avoiding vividly patterned rugs and

drapes; placing locks up high or down low on doors leading outside (AD sufferers

are known to wander off); clearing floors of clutter; reducing the contents of

closets in order to simplify choices (Alzheimer,1992, p.17). These costs are

paid for by the victim's family. Many of these, and other more expensive

modifications are introduced in long-term care settings. They help in

maintaining the safety and security of the victim as well as reducing their

confusion.

The patient's and the family's condition should be assessed every six

months (Alzheimer,1992, p.21). In response to constantly changing needs, the

aspects of care must be constantly modified....

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